Rapid Nanopore Whole-Genome Sequencing for Anthrax Emergency Preparedness

Researchers completed Bacillus anthracis nanopore whole-genome sequencing from a human anthrax isolate hours after receipt. The de novo assembled genome showed no evidence of known antimicrobial resistance genes or introduced plasmid(s). Same-day genomic characterization enhances public health emergency response.

Illuminating anthrax

The US Defense Threat Reduction Agency’s Chemical and Biological Technologies Department (DTRA CB) has a new test that reduces the time needed to determine clearance decontamination for anthrax.

Use of Anthrax Vaccine in the United States: Recommendations of the Advisory Committee on Immunization Practices, 2019

This report updates the 2009 recommendations from the US Centers for Disease Control and Prevention (CDC) Advisory Committee on Immunization Practices (ACIP) regarding use of anthrax vaccine in the United States. The report summarizes data on estimated efficacy in humans using a correlates of protection model and safety data and provides updated guidance for use of anthrax vaccine adsorbed for preexposure prophylaxis.

Stripping Down Bacterial Armor: A New Way to Fight Anthrax

A new study showing that removing the S-layer armor (a single layer of protein) that surrounds the bacterium Bacillus anthracis slows its growth and decreases its ability to cause disease. The researchers successfully applied small antibody fragments to control the assembly of the S-layer armor itself, which had an additional benefit in breaking down existing S-layers.