The London School of Hygiene & Tropical Medicine Antimicrobial Resistance Center, together with the MARCH and Malaria Centres will jointly host the Mass Drug Administration and Antimicrobial Resistance Symposium on 20 February 2019 in London, UK and by live stream. This symposium will bring together academics from a range of relevant disciplines to discuss the state of evidence, and draw out a future integrated research agenda that addresses potential hurdles with this approach, including concerns about antimicrobial resistance.
The US National Biodefense Strategy, released last year, highlights the need to reduce the emergence and spread of superbugs both domestically and internationally, and accelerate the development of new drugs, diagnostic tests, and vaccines.
Researchers developed a genome-scale metabolic network reconstruction of Chromobacterium violaceum and translated it into a mathematical model. A technique called constraints-based flux balance modeling is then used to compute cell function/phenotype. These methods are scalable and can be extended to any infection causing pathogen.
Host-directed therapy can boost a patient’s immune response instead of relying only on antibiotics.
Researchers analysing soil from Ireland long thought to have medicinal properties have discovered that it contains a previously unknown strain of bacteria which is effective against four of the top six superbugs that are resistant to antibiotics.
Infections that were once easily treatable now require extraordinary doses of one or more antibiotics. Meanwhile, intravenous antibiotics with nicknames like “last resort” come off the shelf more and more often.
Resistant strains of bacteria can soldier through a dose of beta-lactam antibiotics with little disturbance to their population levels. Resilient strains, however, suffer a population crash before their community can secrete enough beta-lactamase enzymes to degrade the antibiotic to a tolerable level.
As well as the overall reduction, the UK Government report shows a further drop in sales of the highest priority antibiotics that are critically important for human health.
A new test dubbed DETECT can diagnose patients with antibiotic-resistant infections in a matter of minutes and help limit the spread of antibiotic-resistant superbugs.
Accepting that antibiotics are infrastructure would change our relationship to the drugs, forcing us to recognize that medicine requires long-term planning.