Patients harboring E. coli with highly resistant MCR-1 gene found In NYC hospital

Researchers have identified a cluster of four patients harboring Escherichia coli carrying a rare antibiotic resistance gene, mcr-1. That gene renders the microbe resistant to colistin, an antibiotic of last resort. Three of those patients showed no symptoms, raising the risk of spread.

Association between urinary community-acquired fluoroquinolone-resistant Escherichia coli and neighborhood antibiotic consumption: a population-based case-control study

These data suggest that increased use of antibiotics in specific geographical areas is associated with an increased personal risk of acquiring antibiotic-resistant bacteria, independent of personal history of antibiotic consumption and other known risk factors for antimicrobial resistance.

Mass Drug Administration and Antimicrobial Resistance

The London School of Hygiene & Tropical Medicine Antimicrobial Resistance Center, together with the MARCH and Malaria Centres will jointly host the Mass Drug Administration and Antimicrobial Resistance Symposium on 20 February 2019 in London, UK and by live stream. This symposium will bring together academics from a range of relevant disciplines to discuss the state of evidence, and draw out a future integrated research agenda that addresses potential hurdles with this approach, including concerns about antimicrobial resistance.

Death of the Superbug: Using Computer Models to Identify Mechanisms’ Targetable Vulnerabilities

Researchers developed a genome-scale metabolic network reconstruction of Chromobacterium violaceum and translated it into a mathematical model. A technique called constraints-based flux balance modeling is then used to compute cell function/phenotype. These methods are scalable and can be extended to any infection causing pathogen.