Mass Drug Administration and Antimicrobial Resistance

The London School of Hygiene & Tropical Medicine Antimicrobial Resistance Center, together with the MARCH and Malaria Centres will jointly host the Mass Drug Administration and Antimicrobial Resistance Symposium on 20 February 2019 in London, UK and by live stream. This symposium will bring together academics from a range of relevant disciplines to discuss the state of evidence, and draw out a future integrated research agenda that addresses potential hurdles with this approach, including concerns about antimicrobial resistance.

Death of the Superbug: Using Computer Models to Identify Mechanisms’ Targetable Vulnerabilities

Researchers developed a genome-scale metabolic network reconstruction of Chromobacterium violaceum and translated it into a mathematical model. A technique called constraints-based flux balance modeling is then used to compute cell function/phenotype. These methods are scalable and can be extended to any infection causing pathogen.

Bacteria found in ancient Irish soil halts growth of superbugs—new hope for tackling antibiotic resistance

Researchers analysing soil from Ireland long thought to have medicinal properties have discovered that it contains a previously unknown strain of bacteria which is effective against four of the top six superbugs that are resistant to antibiotics.

Distinguishing resistance from resilience to prolong antibiotic potency

Resistant strains of bacteria can soldier through a dose of beta-lactam antibiotics with little disturbance to their population levels. Resilient strains, however, suffer a population crash before their community can secrete enough beta-lactamase enzymes to degrade the antibiotic to a tolerable level.