Emergence of Extensively Drug-Resistant Salmonella Typhi Infections Among Travelers to or from Pakistan — United States, 2016–2018

A large typhoid fever outbreak in Pakistan has resulted in 5,372 XDR Typhi cases reported during 2016–2018, and five travel-related cases in the United States.

Typhoid fever – Islamic Republic of Pakistan: Disease outbreak news - 27 December 2018

Pakistan Health Authorities have reported an ongoing outbreak of extensively drug resistant typhoid fever that began in the Hyderabad district of Sindh province in November 2016. An increasing trend of typhoid fever cases caused by antimicrobial resistant strains of Salmonella enterica serovar Typhi (or S. Typhi) poses a notable public health concern.

CTX-M-65 Extended-Spectrum β-Lactamase–Producing Salmonella enterica Serotype Infantis, United States

Extended-spectrum β-lactamases (ESBLs) confer resistance to clinically important third-generation cephalosporins, which are often used to treat invasive salmonellosis. In the United States, ESBLs are rarely found in Salmonella. However, in 2014, the US Food and Drug Administration found blaCTX-M-65 ESBL-producing Salmonella enterica serotype Infantis in retail chicken meat.

Outbreak of multidrug-resistant tuberculosis in South Africa undetected by WHO-endorsed commercial tests: an observational study

A substantial number of multidrug-resistant tuberculosis cases harboring the Ile491Phe mutation in the rpoB gene in South Africa are missed by current diagnostic strategies.