A large typhoid fever outbreak in Pakistan has resulted in 5,372 XDR Typhi cases reported during 2016–2018, and five travel-related cases in the United States.
Pakistan Health Authorities have reported an ongoing outbreak of extensively drug resistant typhoid fever that began in the Hyderabad district of Sindh province in November 2016. An increasing trend of typhoid fever cases caused by antimicrobial resistant strains of Salmonella enterica serovar Typhi (or S. Typhi) poses a notable public health concern.
Researchers at an Indian hospital have identified strains of hypervirulent, carbapenem-resistant Klebsiella pneumoniae associated with extremely high mortality rates. The findings represent the first report of a hypervirulent form of the drug-resistant pathogen in India.
Extended-spectrum β-lactamases (ESBLs) confer resistance to clinically important third-generation cephalosporins, which are often used to treat invasive salmonellosis. In the United States, ESBLs are rarely found in Salmonella. However, in 2014, the US Food and Drug Administration found blaCTX-M-65 ESBL-producing Salmonella enterica serotype Infantis in retail chicken meat.
In Hyderabad, Pakistan, an outbreak of extensively drug-resistant (XDR) Salmonella enterica ssp. enterica serovar Typhi was recognized in November 2016 and has now spread to Karachi, home to more than 14 million people.
A substantial number of multidrug-resistant tuberculosis cases harboring the Ile491Phe mutation in the rpoB gene in South Africa are missed by current diagnostic strategies.
Researchers comparing clonal strains of the mycobacteria that cause tuberculosis, before and after they developed resistance to a first-line drug, found that a single genetic change may not always have identical effects on bacterial fitness.
Superbug infections kill 700 people each year in Hong Kong’s public hospitals, fuelled by overuse of antibiotics in healthcare and farming sectors.
Health officials investigating a multistate outbreak of multidrug-resistant Salmonella linked to a variety of raw turkey products and based on detection in live birds are warning that the strain might be widespread in the turkey industry.
In the past 6 months, more than 2000 people in Pakistan have been infected with extensively drug-resistant (XDR) Salmonella typhi.