The US Centers for Disease Control and Prevention (CDC) reports the US had an average of seven human Eastern equine encephalitis over the past decade - in 2019 that number was at least five times higher.
The trial will evaluate the safety, tolerability, and immunogenicity of MVA-BN WEV in 45 healthy adults in three treatment groups receiving different doses of the vaccine.
Nine people from four states have died this year in the US from Eastern equine encephalitis (EEE) virus, a mosquito-borne illness that has a death rate of 30 to 50 percent. Most of the deaths occurring in recent weeks.
The mosquito-borne virus was detected in an adult from the town of East Lyme.
Florida health officials have also reported positive Eastern equine encephalitis cases in one emu, one eagle, and 34 sentinel chickens from 17 counties.
A new vaccine provided complete protection, in nonhuman primates, against three types of equine encephalitic viruses that are possible bioterrorism agents.
The study revealed extensive genetic diversity as well as spatial dispersal of EEEV within Florida. Additionally, Das and colleagues observed more clustering of the disease in the Panhandle region. The findings, they said, indicate that EEEV is present year-round in the Florida Panhandle and that the region could be “seeding” EEEV epizootics in the rest of the state and the Northeastern US.
Madariaga virus (MADV), also known as South American eastern equine encephalitis virus, has been identified in animals and humans in South and Central America, but not previously in Hispaniola or the northern Caribbean.
Health officials say a resident of western Michigan has been infected with Eastern equine encephalitis.
There are new concerns over eastern equine encephalitis, as two human cases have been reported in Central Florida.