Intradermal immunization by Ebola virus GP subunit vaccines using microneedle patches protects mice against lethal EBOV challenge

Researechers compared immune responses induced by Ebola virus glycoprotein subunit vaccines via intradermal immunization with microneedle (MN) patches and the conventional intramuscular injection in mice.

Broadly acting antibodies found in plasma of Ebola survivors

Scientists have discovered a set of powerful, broadly neutralizing antibodies in the blood of Ebola virus disease survivors. In animal studies, two of these antibodies provided substantial protection against disease caused by Zaire ebolavirus, Bundibugyo ebolavirus and Sudan ebolavirus, the three species known to cause fatal human illness.

Safeguarding against Ebola: Vaccines and therapeutics to be stockpiled for future outbreaks

There are challenges that must be overcome to ensure adequate preparedness for future Ebola outbreaks, including completing the remaining advanced development activities necessary for regulatory approval and subsequent stockpiling of medical countermeasures for use during a public health emergency.