Researchers described a method of rendering CRISPR-Cas9 "immunosilent," potentially allowing the editing and repair of genes to be accomplished reliably and stealthily.
Research demonstrates the feasibility of using type I CRISPR-Cas to effectively introduce a spectrum of long-range chromosomal deletions with a single RNA guide in human embryonic stem cells and HAP1 cells. Type I CRISPR systems rely on the multi-subunit ribonucleoprotein (RNP) complex Cascade to identify DNA targets and on the helicase-nuclease enzyme Cas3 to degrade DNA processively.
Scientists have developed a method to boost the efficiency of CRISPR gene editing in Duchenne muscular dystrophy, according to a study that could have implications for optimizing gene therapies for other diseases.
CRISPR has transformed many areas of biology but using this tool to enhance certain varieties of crops such as wheat and corn remains difficult because of the plants’ tough cell walls. Now, an agricultural company has solved that problem by using pollen from one genetically modified plant to carry CRISPR’s components into another plant’s cells.
Alex Kelly, BioFoundry’s 26-year-old lab manager, compares biotech to the birth of the computer, once cloistered in big corporations, now at everyone’s fingertips. Upskill the people in biotech, Kelly believes, and you’ll get disruption writ large, with a potentially massive payoff for the most disadvantaged.
The brains of two genetically edited girls born in China last year may have been changed in ways that enhance cognition and memory, scientists say.
Powerful gene-editing tool could help to diagnose illnesses such as Lassa fever early and rein in the spread of infection.
The World Health Organization (WHO) announced the formation of an international committee aimed at establishing uniform guidelines for editing human DNA in ways that can be passed down to future generations.
From battling disease in banana crops to overcoming avian flu, scientists are seeking wider acceptance for gene editing technology use in agriculture.
Researchers at The Pirbright Institute have published their procedures on video for creating a vaccine that protects against Marek’s disease and infectious bursal disease (IBD) using a CRISPR/Cas 9 gene editing system.