A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes

CRISPR–Cas9 nucleases have been applied in gene drive constructs to target endogenous sequences of the human malaria vectorsA. gambiae and A. stephensi with the objective of vector control.

Efficacy of Olyset Duo, a bednet containing pyriproxyfen and permethrin, versus a permethrin-only net against clinical malaria in an area with highly pyrethroid-resistant vectors in rural Burkina Faso: a cluster-randomized controlled trial

Substantial reductions in malaria incidence in sub-Saharan Africa have been achieved with massive deployment of long-lasting insecticidal nets, but pyrethroid resistance threatens control