Efficacy of an Adjuvanted Middle East Respiratory Syndrome Coronavirus Spike Protein Vaccine in Dromedary Camels and Alpacas

Research found that vaccination with an adjuvanted Middle East respiratory syndrome (MERS) Spike protein subunit vaccine confers complete protection from MERS disease in alpaca and results in reduced and delayed viral shedding in the upper airways of dromedary camels. Together, these data indicate that induction of robust neutralizing humoral immune responses by vaccination of naïve animals reduces shedding that potentially could diminish the risk of zoonotic transmission.

WHO says two events boosted Saudi hospital MERS outbreak

Nine healthcare workers are among the 39 Middle East respiratory syndrome (MERS) patients identified in a hospital-based outbreak of the virus in Wadi ad-Dawasir, and according to the World Health Organization's (WHO) technical lead the outbreak features both human-to-human transmission patterns and spread from animals.

Global status of Middle East respiratory syndrome coronavirus in dromedary camels: a systematic review

The review compiled and analyzed all published data on Middle East respiratory syndrome (MERS) in the global camel population to provide an overview of current knowledge on the distribution, spread and risk factors of infections in dromedary camels.

What Have We Learned About Middle East Respiratory Syndrome Coronavirus Emergence in Humans? A Systematic Literature Review

There has been substantial MERS-CoV research since 2012, but significant knowledge gaps persist, especially in epidemiology and natural history of the infection. There have been few rigorous studies of baseline prevalence, transmission, and spectrum of disease.