An epidemiological investigation identified five clinical cases of secondary monkeypox infection spread over three waves of intrafamilial infection, originating from an index case- with a primary infection.
A Nigerian national has tested positive for monkeypox, the first case of the disease reported in Singapore.
Recently, concern has been raised about the emergence of human monkeypox virus and the occasionally severe clinical presentation bearing resemblance to that of smallpox.
Monkeypox virus is a zoonotic disease endemic to Africa. In 2017, research confirmed a case of human monkeypox virus in Sierra Leone by molecular and serologic methods. Sequencing analysis indicated the virus belongs to the West African clade and data suggest it was likely transmitted by wild animals.
This paper summarizes clinical syndromes and possible treatment options, for both developed and low-resource settings, and offer performance indicators and clinical metrics for case management.
Since the beginning of the outbreak in September 2017, 311 suspected cases and 7 deaths have been reported in 26 states.
Since March 2018, 35 total cases of monkeypox have been recorded (24 confirmed), including two fatalities.
As of December 13, 2018, the Nigerian Centre for Disease Control (NCDC) reported 45 confirmed Monkeypox virus cases during 2018.
Most of the scientific literature about statistical thresholds for outbreak detection is biased toward large datasets that derive from wealthy countries.
Over the past 20 years ten Central and West African countries have reported monkeypox cases which have risen exponentially.