Pandemic Influenza Vaccine: An Investment in Preparedness that Lasts More Than a Decade

As part of our nation’s overall pandemic preparedness strategy, the US Department of Health and Human Services (HHS) set a preparedness goal of establishing and maintaining a stockpile of bulk vaccine antigen and adjuvants for influenza viruses with pandemic potential to vaccinate 26 million people immediately after a pandemic is declared.

Safety and immunogenicity of influenza A(H5N1) vaccine stored up to twelve years in the National Pre-Pandemic Influenza Vaccine Stockpile (NPIVS)

The US Biomedical Advanced Research and Development Authority (BARDA) conducted a randomized, double-blinded Phase 2 clinical study with the oldest stockpiled influenza A(H5N1) antigen, stored over the previous 10–12 years administered with or without MF59® adjuvant, stored over the previous 2–7 years at the time of vaccination.

A shot-in-the-dark email leads to a century-old family treasure — and hope of cracking a deadly flu

The pandemic occurred before the age of molecular virology. Back then it wasn’t even known what caused influenza; influenza viruses were first detected in 1930. In the decades that followed, though, it was recognized that the pandemic was caused by an influenza A virus of the H1N1 subtype. In the late 1990s, U.S. army scientists found and deciphered the virus’s genetic code.

FluLabSurge 1.0.

This software allows laboratory directors and emergency planners to estimate the daily number of specimens expected to be received for testing and the laboratory’s testing capacity during each pandemic stage.

CommunityFlu 2.0

This software allows users to simulate the effects of various interventions – including vaccination, school closure, facemasks, and patient isolation – on the spread of an influenza pandemic.