Researchers completed Bacillus anthracis nanopore whole-genome sequencing from a human anthrax isolate hours after receipt. The de novo assembled genome showed no evidence of known antimicrobial resistance genes or introduced plasmid(s). Same-day genomic characterization enhances public health emergency response.
Bionanosensors may make it quicker and easier to detect harmful micro-organisms, but hurdles remain before they can enter the clinical realm.
HRMAn uses deep neural networks to analyse complex patterns in images of pathogen and human ('host') cell interactions, pulling out the same detailed characteristics that scientists do by-hand.
Epidemiologists, veterinarians, and laboratory technicians from across Kyrgyzstan participated in a five-day specialized training to deepen their knowledge on existing diagnostic methods and procedures to prevent outbreaks caused by high-threat pathogens – such as anthrax, cholera, rabies, and brucellosis.
For the past 30 years, researchers have been investigating paper-based devices for faster diagnostics because paper-like materials, such as glass fiber and cellulose, are robust and known to function as a pump.
Los Alamos National Laboratory (LANL) researchers designed a Universal Bacterial Sensor—modeled after the human innate immune system—that mimics the biological recognition of all categories of bacterial pathogens. Requiring less than a drop of blood, it detects all pathogens without prior knowledge of what they might be, before symptom onset.
As sequencing becomes more common, the number of publicly available bacterial and viral genomes has doubled. At the rate this work is going, within a few years multiple millions of searchable pathogen genomes will be available—a library of DNA and disease, spread the world over.
Researchers documented the losses associated with 137 pathogens and pests in five major food crops—wheat, rice, maize, potato and soybean—worldwide.
Researchers developed PopPUNK (Population Partitioning Using Nucleotide K-mers), a computational tool for analyzing tens of thousands of bacterial genomes in a single run, up to 200-fold faster than previous methods.
Since 2009, the development of new laboratory techniques has fine tuned the detection and identification of pathogens. Whole genome sequencing is largely responsible for those improvements.