HIV infection causes a loss of immunity to smallpox, even in people who were vaccinated as kids and are taking antiretroviral drugs.
Researchers assigned 440 participants to receive two doses of MVA followed by one dose of the established replicating-vaccinia vaccine ACAM2000 (the MVA group) or to receive one dose of ACAM2000 (the ACAM2000-only group). No safety concerns associated with the MVA vaccine were identified, and immune responses and attenuation of the major cutaneous reaction suggest the MVA vaccine protected against variola infection.
The California woman began working with the vaccinia virus at a laboratory in September 2018.
The US Food and Drug Administration (FDA) has given approval of Jynneos Smallpox and Monkeypox Vaccine, Live, This is the only currently FDA-approved vaccine for the prevention of monkeypox disease.
The US Department of Health and Human Services (HHS) issued contract supports the continued supply of ACAM2000 (Smallpox (Vaccinia) Vaccine, Live) into the US Strategic National Stockpile.
The trial will evaluate the immunogenicity and safety of three consecutive vaccine lots of the freeze-dried formulation of MVA-BN®smallpox vaccine.
Planning for a reemergent epidemic of smallpox requires surge capacity of space, resources, and personnel within health systems.
The US Department of Health and Human Services (HHS) awarded a contract for $535 to Emergent BioSolutions Inc. for Vaccinia Immune Globulin Intravenous (VIGIV) to be used in the Strategic National Stockpile. VIGIV is the only therapeutic licensed by the US Food and Drug Administration (FDA) for the treatment of complications due to smallpox vaccination.
Researchers at Rochester Clinical Research are helping to test a new smallpox vaccine.
Buying samples of synthetic DNA is surprisingly easy. The trade is overseen by the International Gene Synthesis Consortium, an industry-led group that works with government agencies to screen orders and buyers. But such oversight can’t prevent someone from purchasing hazardous DNA samples on the black market.