Two doses of the vaccine provided complete protection against both inhalational anthrax and pneumonic plague in animal models. Further, results establish the T4 nanoparticle as a novel platform to develop multivalent vaccines against pathogens of high public health significance.
The Walter Reed Army Institute of Research (WRAIR) this week administered the first vaccine in a Phase 1 clinical trial to evaluate the safety and immunogenicity of a Marburg vaccine candidate in healthy adult volunteers.
A new vaccine against both rabies and Lassa has demonstrated effective protection in animal models of disease, the research also points to a new way to test for protection against the Lassa fever virus, a finding that could significantly speed vaccine development.
The Coalition for Epidemic Preparedness Innovations (CEPI) has announced a collaboration to advance the development and manufacture of a vaccine against Middle East respiratory syndrome coronavirus (MERS-CoV) along with preclinical development of novel vaccines against Lassa and Nipah viruses.
Scientists hope that a new approach to vaccine development, combined with improved surveillance of potential future threats of outbreak, could help to massively reduce the impact of deadly diseases such as Ebola, Marburg and Lassa fever.
There has been widespread skepticism in the scientific community that an effective tuberculosis vaccine would be technically feasible and in industry that it can be economically viable.
Researchers created an H5N1 vaccine, administered through a microneedle that only penetrates the upper layer of the skin. This prototype technology offers a platform that could lead to vaccine patches that can be distributed rapidly and administered without a nurse.
Currently available vaccines for the prevention of seasonal influenza virus infection have limited ability to induce immunity against diverse H3N2 viruses, an influenza A subtype that has led to high morbidity and mortality in recent years.
The new vaccine is composed of virus like particles (VLPs), which are effectively modified outer shells of the foot and mouth disease (FMD) virus that contain no genetic material.
The purpose of these case studies is to familiarize participants with case definitions and with the epidemiological investigation of viscerotropic disease (VTD) associated with vaccination against yellow fever.