Current through March 24, the Brazil Ministry of Health has reported 492 confirmed cases of yellow fever including 162 confirmed deaths. There are an additional 1101 cases under investigation.
The spread of yellow fever towards major population centers has raised alarm.
Brazil, home to one of only four yellow fever vaccine manufacturers in the world, normally produces enough vaccine to meet its needs.
Confirmed cases stand at 396 with a total of 134 deaths.
Four arboviruses have recently emerged or reemerged in the Americas.
The entire state of Espirito Santo is now considered at risk for yellow fever transmission, according to the World Health Organization (WHO).
The downward trend in cases has been observed in the four administrative regions of Minas Gerais.
Estimated fatality rates are 35 percent for confirmed cases and 12 percent for suspected cases.
Officials have declared an emergency situation in 63 cities in Minas Gerais and one in Espirito Santo. Additionally, they are sending millions of extra doses of vaccine to three states.
A malaria epidemic of more than three million cases in 2015, and another four million cases in 2016 has also strained the health system.