The vaccine will be tested on 120 volunteers between 18 and 35.
There are now 14 people with the Zika virus in Florida.
There are about 5,500 confirmed infections on the island, but the US Centers for Disease Control and Prevention believe that is a radical undercount.
Florida officials link cases of the Zika virus to local mosquitoes in the mainland US for the first time.
In 2016, the global health community has made research and public health their top priority in the battle against Zika.
Scientists predict that a Zika vaccine which protects against one strain of the virus will be effective against all virus strains.